Having formed and uneasy alliance with the vampire lord, Xavier Drake, and the monsters that follow him, Blair Spencer and her human team prepare to escort them to their base where they can use Drake's blood to create a cure for the virus. But an unexpected attack by Blood Hunters destroys their transport leaving them stranded in Chicago and hundreds of miles from their destination. With the clock ticking Blair and Xavier must figure out a way to bring their teams together in order survive both the blood thirsty creatures created by the virus, and a new enemy that may be more even more deadly.